Development of T cell receptor repertoires during childhood in health and disease
By Emma A., Bunia A., Othilia FS., Tobias C. & Joanna R.
Group 21
Introduction
Based on the article Mitchell et al. (2022) Allele repertoire development during childhood and type 1 diabetes Two groups of patients, case and control Returns four times for observations
Materials:
1. Data from immunoSEQ ANALYZER
Methods:
1. Base R 1. Tidyverse R 2. PCA analysis 3. MCA analysis
Data Description
Original data (01_dat_load.tsv)
[1] 359 12
# A tibble: 359 × 2 sample_name sample_tags <chr> <chr> 1 310183_TCRB 06 Years, 6 Years at visit, Caucasian, Control, Control 022, GAD… 2 310110_TCRB 0 Years at visit, 09 Months, 6.37808219178082 Years at diagnosis… 3 310206_TCRB 0 Years at visit, 10 Months, 10.558904109589 Years at diagnosis,… 4 310288_TCRB 09 Years, 9 Years at visit, 9.56986301369863 Years at diagnosis,… 5 310271_TCRB 02 Years, 2 Years at visit, 6.87397260273973 Years at diagnosis,… 6 310244_TCRB 05 Years, 18.0438356164384 Years at diagnosis, 5 Years at visit,… 7 310137_TCRB 07 Years, 7 Years at visit, Caucasian, Control, Control 014, Fem… 8 310258_TCRB 12 Years, 12 Years at visit, 12.958904109589 Years at diagnosis,… 9 310127_TCRB 04 Years, 11.6821917808219 Years at diagnosis, 4 Years at visit,…10 310300_TCRB 17 Years, 17 Years at visit, 17.7561643835616 Years at diagnosis…# ℹ 349 more rows